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Childhood onset asthma

MedGen UID:
538550
•Concept ID:
C0264408
•
Disease or Syndrome
Synonyms: asthma of childhood; Childhood asthma; childhood asthma; childhood onset asthma; paediatric asthma; pediatric asthma
SNOMED CT: Childhood asthma (233678006)
 
Monarch Initiative: MONDO:0005405

Definition

Asthma that starts in childhood. [from MONDO]

Professional guidelines

PubMed

ORMDL3/GSDMB genotype as a risk factor for early-onset adult asthma is linked to total serum IgE levels but not to allergic sensitization.
Kitazawa H, Masuko H, Kanazawa J, Shigemasa R, Hyodo K, Yamada H, Yatagai Y, Kaneko Y, Iijima H, Naito T, Saito T, Noguchi E, Konno S, Hirota T, Tamari M, Sakamoto T, Hizawa N
Allergol Int 2021 Jan;70(1):55-60. Epub 2020 May 20 doi: 10.1016/j.alit.2020.04.009. PMID: 32444308
Doublesex and mab-3 related transcription factor 1 (DMRT1) is a sex-specific genetic determinant of childhood-onset asthma and is expressed in testis and macrophages.
Schieck M, Schouten JP, Michel S, Suttner K, Toncheva AA, Gaertner VD, Illig T, Lipinski S, Franke A, Klintschar M, Kalayci O, Sahiner UM, Birben E, Melén E, Pershagen G, Freidin MB, Ogorodova LM, Granell R, Henderson J, Brunekreef B, Smit HA, Vogelberg C, von Berg A, Bufe A, Heinzmann A, Laub O, Rietschel E, Simma B, Genuneit J, Jonigk D, Postma DS, Koppelman GH, Vonk JM, Timens W, Boezen HM, Kabesch M
J Allergy Clin Immunol 2016 Aug;138(2):421-31. Epub 2016 Feb 20 doi: 10.1016/j.jaci.2015.12.1305. PMID: 26906082
IFNG genotype and sex interact to influence the risk of childhood asthma.
Loisel DA, Tan Z, Tisler CJ, Evans MD, Gangnon RE, Jackson DJ, Gern JE, Lemanske RF Jr, Ober C
J Allergy Clin Immunol 2011 Sep;128(3):524-31. Epub 2011 Jul 27 doi: 10.1016/j.jaci.2011.06.016. PMID: 21798578Free PMC Article

Recent clinical studies

Etiology

Assessing causal relationships between gut microbiota and asthma: evidence from two sample Mendelian randomization analysis.
Li R, Guo Q, Zhao J, Kang W, Lu R, Long Z, Huang L, Chen Y, Zhao A, Wu J, Yin Y, Li S
Front Immunol 2023;14:1148684. Epub 2023 Jul 19 doi: 10.3389/fimmu.2023.1148684. PMID: 37539057Free PMC Article
Asthma and the risk of gastrointestinal disorders: a Mendelian randomization study.
Freuer D, Linseisen J, Meisinger C
BMC Med 2022 Mar 16;20(1):82. doi: 10.1186/s12916-022-02283-7. PMID: 35292014Free PMC Article
Asthma-COPD Overlap: What Are the Important Questions?
Leung C, Sin DD
Chest 2022 Feb;161(2):330-344. Epub 2021 Oct 6 doi: 10.1016/j.chest.2021.09.036. PMID: 34626594
Genetics and Epigenetics in Asthma.
Ntontsi P, Photiades A, Zervas E, Xanthou G, Samitas K
Int J Mol Sci 2021 Feb 27;22(5) doi: 10.3390/ijms22052412. PMID: 33673725Free PMC Article
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
Pividori M, Schoettler N, Nicolae DL, Ober C, Im HK
Lancet Respir Med 2019 Jun;7(6):509-522. Epub 2019 Apr 27 doi: 10.1016/S2213-2600(19)30055-4. PMID: 31036433Free PMC Article

Diagnosis

Assessing causal relationships between gut microbiota and asthma: evidence from two sample Mendelian randomization analysis.
Li R, Guo Q, Zhao J, Kang W, Lu R, Long Z, Huang L, Chen Y, Zhao A, Wu J, Yin Y, Li S
Front Immunol 2023;14:1148684. Epub 2023 Jul 19 doi: 10.3389/fimmu.2023.1148684. PMID: 37539057Free PMC Article
Comorbidities in childhood-onset and adult-onset asthma.
Mendy A, Mersha TB
Ann Allergy Asthma Immunol 2022 Sep;129(3):327-334. Epub 2022 May 18 doi: 10.1016/j.anai.2022.05.005. PMID: 35595004Free PMC Article
Asthma and the risk of gastrointestinal disorders: a Mendelian randomization study.
Freuer D, Linseisen J, Meisinger C
BMC Med 2022 Mar 16;20(1):82. doi: 10.1186/s12916-022-02283-7. PMID: 35292014Free PMC Article
Asthma-COPD Overlap: What Are the Important Questions?
Leung C, Sin DD
Chest 2022 Feb;161(2):330-344. Epub 2021 Oct 6 doi: 10.1016/j.chest.2021.09.036. PMID: 34626594
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
Pividori M, Schoettler N, Nicolae DL, Ober C, Im HK
Lancet Respir Med 2019 Jun;7(6):509-522. Epub 2019 Apr 27 doi: 10.1016/S2213-2600(19)30055-4. PMID: 31036433Free PMC Article

Therapy

Higher risk of osteoporosis in adult-onset asthma than childhood-onset asthma: from genetic and prospective evidence.
Ding W, Huang Y, Li G, Dong Y, Li X, Wu M, Song K, Li F
Osteoporos Int 2024 Apr;35(4):659-668. Epub 2023 Dec 23 doi: 10.1007/s00198-023-07004-1. PMID: 38141141
Assessing causal relationships between gut microbiota and asthma: evidence from two sample Mendelian randomization analysis.
Li R, Guo Q, Zhao J, Kang W, Lu R, Long Z, Huang L, Chen Y, Zhao A, Wu J, Yin Y, Li S
Front Immunol 2023;14:1148684. Epub 2023 Jul 19 doi: 10.3389/fimmu.2023.1148684. PMID: 37539057Free PMC Article
Asthma and the risk of gastrointestinal disorders: a Mendelian randomization study.
Freuer D, Linseisen J, Meisinger C
BMC Med 2022 Mar 16;20(1):82. doi: 10.1186/s12916-022-02283-7. PMID: 35292014Free PMC Article
The role of atopy in asthma development and persistence.
Di Cicco M, D'Elios S, Peroni DG, Comberiati P
Curr Opin Allergy Clin Immunol 2020 Apr;20(2):131-137. doi: 10.1097/ACI.0000000000000627. PMID: 31985546
Childhood asthma: recent developments and update.
Mantzouranis E, Papadopouli E, Michailidi E
Curr Opin Pulm Med 2014 Jan;20(1):8-16. doi: 10.1097/MCP.0000000000000014. PMID: 24240439

Prognosis

Genetics of preschool wheeze and its progression to childhood asthma.
Wolters AAB, Kersten ETG, Koppelman GH
Pediatr Allergy Immunol 2024 Jan;35(1):e14067. doi: 10.1111/pai.14067. PMID: 38284918
Assessing causal relationships between gut microbiota and asthma: evidence from two sample Mendelian randomization analysis.
Li R, Guo Q, Zhao J, Kang W, Lu R, Long Z, Huang L, Chen Y, Zhao A, Wu J, Yin Y, Li S
Front Immunol 2023;14:1148684. Epub 2023 Jul 19 doi: 10.3389/fimmu.2023.1148684. PMID: 37539057Free PMC Article
Asthma and the risk of gastrointestinal disorders: a Mendelian randomization study.
Freuer D, Linseisen J, Meisinger C
BMC Med 2022 Mar 16;20(1):82. doi: 10.1186/s12916-022-02283-7. PMID: 35292014Free PMC Article
Genetics and Epigenetics in Asthma.
Ntontsi P, Photiades A, Zervas E, Xanthou G, Samitas K
Int J Mol Sci 2021 Feb 27;22(5) doi: 10.3390/ijms22052412. PMID: 33673725Free PMC Article
Genetic risks and childhood-onset asthma.
Cookson W, Moffatt M, Strachan DP
J Allergy Clin Immunol 2011 Aug;128(2):266-70; quiz 271-2. doi: 10.1016/j.jaci.2011.06.026. PMID: 21807248

Clinical prediction guides

Age at menarche and asthma onset among US girls and women: findings from NHANES, 2001-2018.
Cai L, Li X, Qiu L, Wang Y, Wu L, Wu X, Xu R, Liu Y, Zhou Y
Ann Epidemiol 2023 Nov;87:25-30. Epub 2023 Aug 19 doi: 10.1016/j.annepidem.2023.08.003. PMID: 37598789
Assessing causal relationships between gut microbiota and asthma: evidence from two sample Mendelian randomization analysis.
Li R, Guo Q, Zhao J, Kang W, Lu R, Long Z, Huang L, Chen Y, Zhao A, Wu J, Yin Y, Li S
Front Immunol 2023;14:1148684. Epub 2023 Jul 19 doi: 10.3389/fimmu.2023.1148684. PMID: 37539057Free PMC Article
Asthma and the risk of gastrointestinal disorders: a Mendelian randomization study.
Freuer D, Linseisen J, Meisinger C
BMC Med 2022 Mar 16;20(1):82. doi: 10.1186/s12916-022-02283-7. PMID: 35292014Free PMC Article
Genetics and Epigenetics in Asthma.
Ntontsi P, Photiades A, Zervas E, Xanthou G, Samitas K
Int J Mol Sci 2021 Feb 27;22(5) doi: 10.3390/ijms22052412. PMID: 33673725Free PMC Article
Shared and distinct genetic risk factors for childhood-onset and adult-onset asthma: genome-wide and transcriptome-wide studies.
Pividori M, Schoettler N, Nicolae DL, Ober C, Im HK
Lancet Respir Med 2019 Jun;7(6):509-522. Epub 2019 Apr 27 doi: 10.1016/S2213-2600(19)30055-4. PMID: 31036433Free PMC Article

Recent systematic reviews

Neonatal jaundice, phototherapy and childhood allergic diseases: An updated systematic review and meta-analysis.
Kuniyoshi Y, Tsujimoto Y, Banno M, Taito S, Ariie T
Pediatr Allergy Immunol 2021 May;32(4):690-701. Epub 2021 Feb 20 doi: 10.1111/pai.13456. PMID: 33475191
Prognosis of new-onset asthma diagnosed at adult age.
Tuomisto LE, Ilmarinen P, Kankaanranta H
Respir Med 2015 Aug;109(8):944-54. Epub 2015 May 21 doi: 10.1016/j.rmed.2015.05.001. PMID: 26052036
The social and economic consequences of childhood asthma across the lifecourse: a systematic review.
Milton B, Whitehead M, Holland P, Hamilton V
Child Care Health Dev 2004 Nov;30(6):711-28. doi: 10.1111/j.1365-2214.2004.00486.x. PMID: 15527481

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